|
KMID : 0881720160310050356
|
|
Journal of Food Hygiene and Safety
2016 Volume.31 No. 5 p.356 ~ p.364
|
|
|
Evaluation of in vivo Genotoxicity of Plant Flavonoids, Quercetin and Isoquercetin
|
|
Park Bum-Soo
Han Se-Hee
Lee Ji-Yeon
Chung Young-Shin
|
|
|
Abstract
|
|
|
|
In vivo genotoxic potential of isoquercetin, a plant common flavonoid, in comparison with quercetin was investigated for the DNA breakage and the clastogenicity endpoints. Male ICR mice were administered by oral gavage for 3 days with 3 x 0.5% carboxymethyl cellulose (CMC), 3 x isoquercetin (250, 500 mg/kg/day), 3 x quercetin (250, 500 mg/kg/day) and 2 x ethyl methanesulfonate (EMS, 200 mg/kg/day). Tissues were collected 48 hours after the first treatment and within 3 hours after the last treatment. The DNA damages were evaluated using Comet assay in liver and stomach, while the clastogenicities were determined using micronucleus test in bone marrow of same animals. The treatment of isoquercetin as well as quercetin did not cause the DNA damages in liver and stomach, and not induce the frequencies of micronucleus polychromatic erythrocytes in bone marrow. In conclusion, isoquercetin as well as quercetin did not cause the DNA breakages and the chromosomal damages in vivo system in these study conditions.
|
|
|
KEYWORD
|
|
|
isoquercetin, quercetin, in vivo genotoxicity, comet assay, micronucleus test
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|